Using Flask with UWGI: http://uwsgi-docs.readthedocs.org/en/latest/WSGIquickstart.html#deploying-flask
Complete tutorial nginx+uwsgi+flask (but I've not used that;-)): http://blog.kramerapps.com/post/22551999777/flask-uwsgi-nginx-ubuntu
How to treat favicon: http://flask.pocoo.org/docs/patterns/favicon/